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Devil May Cry 4

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Mission 7: Easy Orbs
Use the following trick to collect 4,300 Red Orbs in about twenty seconds. At the start of the mission, destroy the rocks to the left of you. Proceed into the tunnel and also destroy the rocks that are there. You will see the big red crystal near the Secret Mission. In order to get the most orbs, start with the Stinger then immediately go into Devil Trigger mode and quickly mash away. Once done, press Start, go to "Systems" then "Retry Mission". This is the easiest way to get a lot of Red Orbs in a short amount of time.

Defeating Demonic Bosses
You can use Nero's Devil Bringer to defeat Demonic Bosses. Before you daze any demonic Boss, get your Devil Trigger as high as possible. As soon as the enemy is dazed, hit the Devil Trigger and use the uppercut on the enemy. Using it in different areas of the enemy's body results in a nice combo.

Defeat Sanctus
Use the following trick to defeat Sanctus inside of Sparda in Mission 20. While Sanctus is airborne in his shield, get close and break it with sword attacks just like earlier in the game. However, he will sometimes block with the Sword of Sparda. When he does this, use the uppercut technique to break his guard. If you are skilled you should use the Devil Trigger while he is in the air to use a special combo to force him to the ground. If you fail to do the air combo just let him fall to the ground. You may be able to get a few sword-based shots in but do not try to rely on this because he may escape. At this point, use the uppercut in Devil Trigger form, if at all possible. Afterwards he will go back to being airborne again, in which case you should drop the Devil Trigger. After you have broken his health down to about the 10% to 15% mark, he will use a charging sword attack (however, if you have perfected the aforementioned combo, you may bypass this). Defeating him requires timing. At the precisely the correct moment of his charge towards you, uppercut and break his guard. Again, as soon as it is broken get into the Devil Trigger uppercut and finish him off. In the second battle against Sanctus, as the False Prophet, timing is once again crucial. All you must do is uppercut his attacks away.

Defeat a Blitz as Nero
To lower the Blitz "electricity shield" quickly, use charged pistol shots with Devil Trigger activated. The most effective method seems to be as follows:

Charge a shot.
Go into Devil Trigger.
Release the shot, maybe a few more.
Turn off Devil trigger, and repeat.
This will quickly give you Super Smokin Stylish before he has even dropped his shield. This will work even with a level 1 Charge Shot, and should be much easier if you have level 3. Once his shield his gone, use Devil Trigger again, and use the Devil Bringer to devastate him. Three throws should be enough to send him into "red mode". Once he goes red he will try to grab you and suicide himself to seriously drain your life, or kill you. Shoot normal shots at him to get more Smokin Stylish points at this point, and finish him off handily.

Complete Ending
After beating Devil May Cry 4 and viewing part of the ending, the credits roll. During this time you have to protect Kyrie from being hit or the credits will end prematurely.
See the rest of the ending
Protect Kyrie during the Credits for 90 seconds

Defeating Berial
Use Grim Grip to reel yourself close to his head, and attack with your sword. Once the combos are done, use Grim Grip while still in the air. When his flames are gone, jump up to his head. Grab his head with the Devil Bringer, then once he lands from that, use Devil Bringer again to throw and punch him. Then, run a short distance away because he will release an explosion around him. Make sure to pick up Green Orbs from the destroyed buildings, and roll to avoid his flame geysers and sword attack. Continue attacking this way, and use your Charge Shot to defeat him in under a minute.